Lithium orotate is an over-the-counter mineral that has been shown to have a positive impact on mood, particularly with stress, irritability and frequent mood swings. May work to calm brain activity and promote positive mood by supporting the brain’s natural detoxification process, emotional wellness and naturally balance neurotransmitters. Mood Stabilizer. May help with various mental health conditions such as anxiety, bipolar disorder, insomnia, migraines and cluster headaches.